But abstinence is a substantial bar comparable to necessitating that an antidepressant make total remission of despair or that an analgesic absolutely eliminate suffering. Recognizing this limitation, the FDA encourages developers of opioid2 and stimulant3 use disorder medicines to discuss with FDA substitute ways to measure variations in drug use https://maps.app.goo.gl/ySf3nrmpAxXCtFGHA