Conolidine’s analgesic effects stem from its interaction with non-opioid pain pathways. Contrary to opioids, which bind to µ-opioid receptors in the central nervous system, conolidine modulates alternate molecular targets. A Science Advancements study observed that conolidine interacts Together with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://manuelpbcdd.madmouseblog.com/19706928/the-basic-principles-of-alternative-natural-pain-relief-to-replace-traditional-painkillers