Lastly, clonidine boosts neuraxial opioids and, in combination with fentanyl, interacts within an additive manner, which can reduce the dose of each part by sixty% for postoperative analgesia. Clonidine treats large blood pressure level by stimulating αtwo receptors during the brainstem, which decreases peripheral vascular resistance, reducing blood pressure. https://www.proleviate.com/post/the-new-pain-killer-conolidine