Summary: Epithelial tissues sustain barrier function by removing and replacing aberrant or unfit cells. Here. we describe approaches to evaluate epithelial restorative capacity after inducing cell loss in zebrafish larvae. We provide details to quantify morphological changes to the tail fin epithelium after cell loss. https://www.alarecre.com/Looney-Tunes-Marvin-the-Martian-Big-Head-Galaxy-S23-Waterproof-Case-p116784/